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Protein Quality Control in Heart Disease: Using Established Drugs to Target Novel Mechanismsâ |
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Τετάρτη, 13 Οκτώβριος 2010 17:30 |
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The heart, along with other cells in the body, requires continuous protein synthesis and degradation, with protein turnover rates of approximately 2% per day. This dynamic process is highly regulated by protein quality control systems that identify and process damaged or misfolded proteins, which increase with stress. Misfolded proteins are escorted by chaperones for repair or disposal via 2 major mechanisms. The ubiquitin-proteosome system (UPS) tags proteins with ubiquitin to identify them for degradation by the 26S proteosome (). Autophagy degrades proteins and organelles by lysosomal proteases (). When these processes are impaired or overwhelmed, protein aggregates can accumulate with potentially toxic effects. (Source: Journal of the American College of Cardiology)
Source: www.medworm.com
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