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Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity. |
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Τετάρτη, 13 Οκτώβριος 2010 06:15 |
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Authors: Collini P, Noursadeghi M, Sabroe I, Miller RF, Dockrell DH
HIV-1 can establish both long lived and productive infection of macrophages (MÏ) but circulating monocytes are less permissive to infection. Multiple studies have identified extensive changes to monocyte and MÏ phenotype, differentiation or function. These include alterations in Toll-like receptor signaling and resultant changes to cytokine responses, specific defects in phagocytosis and microbial killing and modulation of apoptotic responses, all of which may perturb the important role of these cells in innate immunity. Interpretation of contradictory data however, is complicated by the use of different experimental models and many of the reported effects may be an indirect consequence of HIV 1 infection that result...MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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