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Pannexin 1 channels mediate âfind-meâ signal release and membrane permeability during apoptosis |
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Τρίτη, 12 Οκτώβριος 2010 17:00 |
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Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Nature 467, 7317 (2010). doi:10.1038/nature09413
Authors: Faraaz B. Chekeni, Michael R. Elliott, Joanna K. Sandilos, Scott F. Walk, Jason M. Kinchen, Eduardo R. Lazarowski, Allison J. Armstrong, Silvia Penuela, Dale W. Laird, Guy S. Salvesen, Brant E. Isakson, Douglas A. Bayliss & Kodi S. Ravichandran
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells...
Source: www.medworm.com
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