|
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1 |
|
Τρίτη, 12 Οκτώβριος 2010 17:00 |
 |
 |
 |
|
Authors: Jun Arii, Hideo Goto, Tadahiro Suenaga, Masaaki Oyama, Hiroko Kozuka-Hata, Takahiko Imai, Atsuko Minowa, Hiroomi Akashi, Hisashi Arase, Yoshihiro Kawaoka & Yasushi Kawaguchi
Herpes simplex virus-1 (HSV-1), the prototype of the α-herpesvirus family, causes life-long infections in humans. Although generally associated with various mucocutaneous diseases, HSV-1 is also involved in lethal encephalitis. HSV-1 entry into host cells requires cellular receptors for both envelope glycoproteins B (gB) and D (gD). However, the gB receptors responsible for its broad host range in vitro and infection of critical targets in vivo remain unknown. Here we show that non-muscle myosin heavy chain IIA (NMHC-IIA), a subunit of non-muscle myosin IIA (NM-IIA), functions as an HSV-1 entry r...
Source: www.medworm.com
|
