| The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis | ||||
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Conclusions. Our data indicate that serpinE2 is up-regulated by oncogenic activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic actions of ERK signaling in intestinal epithelial cells. Hence, serpinE2 may be a potential therapeutic target for colorectal cancer treatment. (Source: Molecular Cancer)
Source: www.medworm.com
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