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Expression of Msx-1 is suppressed in bisphosphonate associated osteonecrosis related jaw tissue -etiopathology considerations respecting jaw developmental biology-related unique features |
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Τρίτη, 12 Οκτώβριος 2010 17:00 |
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Conclusions:
These results explain the sclerotic and osteopetrotic changes of periodontal tissue following BP application and substantiate clinical findings of BP-related impaired remodelling specific to periodontal tissue. RANKL suppression substantiated the clinical finding of impaired bone remodelling in BP- and aRANKL-induced ONJ-affected bone structures. Msx-1 suppression in ONJ-adjacent periodontal tissue suggested a bisphosphonate-related impairment in cellular differentiation that occurred exclusively jaw remodelling. Further research on developmental biology-related unique features of jaw bone structures will help to elucidate pathologies restricted to maxillofacial tissue. (Source: Journal of Translational Medicine)
Source: www.medworm.com
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