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Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet |
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Τρίτη, 12 Οκτώβριος 2010 17:00 |
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Conclusions:
Our results point to an important role of all types of sinusoidal cells in regeneration from CDE induced liver damage and call for utmost caution in using traditional marker for identifying specific cell types. Thus, M2-pyruvate kinase should no longer be used for estimating the oval cell response in mouse liver. CDE diet leads to activation of GFAP positive HSCs in the pericentral zone of liver lobulus. In the periportal zone the detection of GFAP in biliary cells and oval cells, calls other cell types as progenitors of hepatocytes into question under CDE diet conditions. (Source: Comparative Hepatology)
Source: www.medworm.com
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