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Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes |
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Τρίτη, 12 Οκτώβριος 2010 17:00 |
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Conclusion:
Our results indicate that ammonia and a mixture of cytokines each cause astrocyte swelling but when these agents are added simultaneously, no additive effects were found. On the other hand, when cells were initially treated with ammonia and 24 h later given a mixture of cytokines, a marked potentiation in cell swelling and NF-kB activation occurred. These data suggest that the potentiation in cell swelling is a consequence of the initial activation of NF-kB by ammonia. These findings provide a likely mechanism for the exacerbation of brain edema in patients with ALF in the setting of sepsis/inflammation. (Source: Journal of Neuroinflammation)MedWorm Message: Watch the new MedWorm demo and find out how to get all the very latest, relevant, organized information daily!
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